Individual Research Project 14

Personalized Ultrasound-based hemodynamics simulations in the diseased abdominal aorta

Maria Nicole Antonuccio – ESR 14
The research of ESR14 will address the issue of estimating non-invasively hemodynamics descriptors in the aorta, such as 3D flow field and internal aortic pressure. The estimations will be based on dynamic Doppler acquisitions of patients with abdominal aortic aneurysms (AAA), enabling the measurements of partial flow velocities in the aneurysms. Accessing these hemodynamics descriptors is non-trivial, although it would enable to build a complete 3D flow map, thanks to the integration of physical principles, using a numerical solver. These hemodynamics parameters can then be used to support the characterization of the arterial wall or the prediction of wall remodelling and intraluminal thrombus (ILT) deposition. Eventually, these 3D flow field maps and patterns will greatly serve to progress in the global understanding of evolution of arterial wall degradation.

Expected Results

  • Non-invasively hemodynamics descriptors in the aorta and assessment.
  • Prediction of wall remodelling and intraluminal thrombus (ILT) deposition.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 859836
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